Answers medicinal-chemistry questions from ChEMBL's curated records.

It gives chemists ChEMBL's curated bioactivity records in one place: which compounds were tested against a target, their measured IC50, Ki or EC50 values, and how approved drugs act.

What it is

A connector Anthropic built and runs at hcls.mcp.claude.com, which reads from ChEMBL, EMBL-EBI's curated database of bioactive molecules. It needs no sign-in and no key.

What you get

Compounds found by name, ChEMBL ID or chemical structure (SMILES)
Targets such as proteins, enzymes and receptors, found by name, gene symbol or organism
Measured activity between a compound and a target, such as IC50, Ki and EC50 values
How an approved drug or clinical candidate acts on its target, for example as an inhibitor or agonist
Approved drugs and clinical candidates for a disease, with their development phase
Calculated drug-likeness properties for a molecule, including Rule of Five checks

Requirements

An MCP client that can reach a remote address. In Claude you add it under Settings > Connectors. In Claude Code you can install it as a plugin from Anthropic's life-sciences marketplace.

Setup effort

Paste a URL — add the endpoint to your client