MCP SERVERLet your AI assistant query OpenGenes for evidence on aging-related genes, lifespan experiments, and human longevity associations.
opengenes-mcp connects AI assistants to OpenGenes research data through read-only SQL queries. It helps researchers explore genetic interventions in model organisms, human longevity associations, and links between genes and aging processes. Schema information and example queries help the assistant work with the database’s tables and fields.
The server can run on your computer, automatically downloading the database and schema documentation and caching them locally. Basic server functionality requires no API key. Queries are limited to SELECT operations, and the server covers only a subset of the full OpenGenes database.
When choosing experiments to investigate, ask which gene knockdowns, knockouts, or overexpression experiments extended lifespan in a particular model organism. Filter the recorded interventions by organism and method to identify relevant genes and compare their reported lifespan effects.
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When evaluating a gene or variant linked to human longevity, retrieve its recorded associations and the populations studied. Questions about FOXO3 polymorphisms or APOE associations across ethnic groups can help you locate the evidence relevant to your research.
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When starting with an aging process rather than a gene, search the gene classifications and hallmark mappings for relevant candidates, such as genes associated with mitochondrial aging processes. You can also investigate recorded links to altered expression with age.
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When a gene becomes a research candidate, ask what types of studies and aging-related evidence OpenGenes records for it. This helps you assemble the available evidence around one gene before deciding which findings to examine further.
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When looking for genes supported by different kinds of research, compare the lifespan experiment records with human longevity associations. Joining the tables by gene symbol identifies genes represented in both datasets for follow-up investigation.
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This directory reflects the tools collected on August 11, 2026.
opengenes_db_queryRun read-only SQL queries against OpenGenes data on longevity-related genes, lifespan experiments in model organisms, and age-related changes in humans and other organisms.
opengenes_example_queriesGet example SQL queries with descriptions as starting points for querying OpenGenes.
opengenes_get_schema_infoInspect the OpenGenes database schema, including tables, columns, and enumerations, to plan SQL queries.
Have uv and uvx available before adding the server to your AI tool; the client configuration selects stdio for the local connection.
If needed, install uv. Make sure uvx is on PATH so Claude Desktop can launch the server.
In Claude Desktop, open Settings → Developer → Edit Config. Add the configuration below and save the file. If you already have an mcpServers object, add the opengenes-mcp entry inside it, keeping your existing servers.
claude_desktop_config.jsonJSON{
"mcpServers": {
"opengenes-mcp": {
"command": "uvx",
"args": ["opengenes-mcp"],
"env": {
"MCP_TRANSPORT": "stdio"
}
}
}
}Allow internet access for the initial package download and for the server to download the OpenGenes database and documentation from Hugging Face. Downloaded data is cached locally.
Completely quit Claude Desktop, then reopen it to load the configuration and start the server.
Check the result
Find the server and its tools
At the bottom left of the conversation input, open “Add files, connectors, and more /” → Connectors → Manage connectors. Select opengenes-mcp and check that its tools are listed, including opengenes_get_schema_info.